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Hydrating Serum with Polypeptides

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This serum, formulated with OHA-tech™, provides intense, long-lasting hydration and counters the visible signs of aging.

Skin Type: Dry, Normal, Oily, Combination, Sensitive

Skin Concerns: Fine lines + wrinkles, Dehydration, Discoloration, Uneven texture

Net Content: 30ml


Our formula combines 10% Argireline™Matrixyl, and an optimal spectrum of HAs (OHA-tech™) to provide:

  • Intense, Multi-Dimensional Hydration Without Clogging Pores
  • Prevent & Smooth Fine Lines
  • Clean: Oil, paraben-, alcohol-, dye-, fragrance-free
  • Vegan & cruelty-free

Preparation: Thoroughly cleanse and tone the skin.

Application: Apply a few drops of serum onto your palm and massage gently onto face.

After: Follow with moisturizer; and sunscreens if applied in the morning

  • Sodium Hyaluronate (OHA-tech™)
  • Acetyl Hexapeptide-8 (Argireline)
  • Palmitoyl Pentapeptide-4 (Matrixyl)
  • Palmitoyl Tripeptide-5
  • Mildly-Acidic Ionized Water
  • Dipotassium Glycyrrhizate
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides
Hydrating Serum with Polypeptides







  • Dr. Jennifer T. Haley, MD FAAD

  • Dr. Anna Chacon, MD FAAD

  • Clinicals Results

  • Ingredients

"I wholeheartedly recommend this serum for its exceptional efficacy and elegant formulation. More than just a wrinkle warrior, it's your ultimate hydration hero. With a unique blend of clean, science-backed ingredients, this serum penetrates deeply to replenish moisture, enhance skin elasticity, even out skin tone, and reduce fine lines and wrinkles. This serum is truly an invaluable addition to elevate your skincare ritual."

Board-Certified Dermatologist

"To enhance your skincare routine with a scientifically advanced product, consider SilkiMED's Hydrating Serum with Polypeptides."

Board-Certified Dermatologist & Teledermatologist

  • 100% agreed that wrinkles became less visible.
  • 93% agreed that their skin became firmer.
  • 100% agreed that their skin became more elastic.
  • 93% agreed that the roughness of their skin improved.
  • 90% agreed that their skin became hydrated and radiant.
  • 97% were satisfied with the product's penetration and absorption.
  • 100% agreed that the product was gentle and non-irritating.

  • Free shipping Over $35

  • 30 Days Risk-Free Returns

  • 100% Secure Payment

  • Happy Customers

  • Proven Results

Clinical Results

The product's hydrating and wrinkle-reducing effects were validated by clinical studies involving 19 female and 11 male volunteers aged 30 to 54, with digital images captured at designated time points using the VISIA system.

  • 50.48%

    Reduction in Wrinkle Quantity

  • 10.56%

    Reduction in Wrinkle Area

  • 27.70%

    Increase in Hydration

  • Subject No. 19

    of the clinical test for Hydrating Serum with Polypeptides after 28 days of use.

  • Subject No. 1

    of the clinical test for Hydrating Serum with Polypeptides after 28 days of use.

Ingredients Highlight

  • OHA-tech™

    OHA-tech™ stands out from traditional hyaluronic acids by featuring an optimal spectrum of HA molecular sizes. This innovative approach comprehensively addresses both internal and external skin hydration needs.

  • Palmitoyl Pentapeptide-4 (Matrixyl)

    A powerful peptide complex, Matrixyl works at a cellular level to promote collagen production and improve skin elasticity. By stimulating the skin's natural renewal processes, Matrixyl helps reduce the appearance of fine lines, wrinkles, and age-related skin damage.

  • Acetyl Hexapeptide-8 (Argireline)

    A powerful peptide celebrated for its efficacy in reducing fine lines and wrinkles. By relaxing facial muscles and supporting collagen, it contributes to a visibly more youthful appearance.

  • Palmitoyl Tripeptide-5

    Renowned for diminishing fine lines and promoting skin firmness. Through its collagen-boosting properties, it actively contributes to a smoother and more resilient complexion.

  • Dipotassium Glycyrrhizate

    As a natural anti-inflammatory agent derived from licorice root, it effectively alleviates skin sensitivity, redness, and irritation while aiding in diminishing dark spots, promoting a more even skin tone.

  • Mildly-Acidic Ionized Water

    This ingredient serves to purify the skin, boost skin immunity, and maintain a healthy pH balance, resulting in a radiant complexion.

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How is SilkiMED’s Hydrating Serum with Polypeptides different?

Clinical Tests for Effectiveness:

We conduct thorough testing in third-party laboratories to ensure the safety and efficacy of our products. We avoid making exaggerated promises, and our claims are substantiated by the results of our clinical trials.

Clinically Formulated:

The development of SilkiMED products undergoes meticulous refinement, incorporating input from skin experts, and customers to ensure both skin compatibility and effectiveness.

Clean Formula:

We meticulously selects safe and potent ingredients essential for our product to be both gentle and effective.

What is OHA-tech™?

Traditional hyaluronic acids (HAs), due to their larger molecular sizes, struggle to effectively penetrate the skin for optimal hydration. Instead, they form a breathable film on the skin's surface, locking in essential nutrients and moisture.

Recognizing the limitations of regular HAs, we employ enzymatic degradation technology to precisely tailor HA molecules into various sizes, ranging from very low molecular weights (Oligo HA) to larger molecular weights. This innovative process allows us to create an optimal spectrum of HAs, offering a comprehensive solution that addresses both internal and external skin hydration needs. This optimization enhances their effectiveness and benefits for the skin.

Who is the serum suitable for?

Whether you have dry, oily, combination, or sensitive skin, you can benefit from its hydrating and anti-aging properties.

However, if you have specific concerns or allergies, we recommend conducting a patch test before applying it to your face.

What's the target age group for this product?

We believe in a proactive approach to skincare.

Whether you're in your 20s, proactively preventing early signs of aging, or in your 40s, aspiring to age gracefully, it's the perfect addition to your skincare routine.

It is particularly ideal for individuals around the age of 25, as this is when initial signs of aging tend to appear.

How long will the product last me?

The 30ml serum should last for around 4 weeks when used as directed.

Can I use this serum with other skincare products?

Absolutely! Our serum's nano-molecular HA not only hydrates but also acts as a potent penetrating agent. This makes it an excellent addition to your skincare routine as it enhances the effectiveness of other valuable ingredients in your other products.

Will this serum make my skin feel greasy or sticky?

Not at all. Our formula is carefully crafted to provide a lightweight and non-greasy texture. It absorbs quickly into the skin, leaving it feeling refreshed, hydrated, and comfortable.

Customer Reviews

Based on 30 reviews

Heard about these from an influencer on Instagram and they did not disappoint. Definitely try gently massaging your face with it on and use the extra liquid after taking the mask off on your neck and chest. Skin looks and feels plump and hydrated.

Skin Type: Combination
Age: 40 - 49

These are some of the best masks I’ve used. Left my skin soft and glowy. I absolutely love them

Skin Type: Combination, Dry, Sensitive
Age: 20 - 29

Wow, my mom and I got the chance to tried out this mask. She loved it “much better than the other two masks”
My skin is drank it up, felt smoother, looks brighter. Did not irritate or break out my sensitive skin.
My mom felt her skin is much smoother and hydrated as well.
Definitely repurchasing and looking to try out their other products!

Maggie Chen
Skin Type: Combination, Sensitive
Age: 30 - 39
Great Serum!!

I love the texture of the serum; it's so lightweight and easy to absorb! After using it, my skin feels both hydrated and soft. I look forward to seeing results as I add this serum to my daily routine!

Gilly Markris
Miracle ingredients. It’s crazy. Results are as claimed and advertised.

Definitely a “wow” product. It doesn’t leave any sticky feelings on my skin either and soaks right in.